(4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide

Base Information

Chemical Name:(4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide
CAS No.:1400924-77-7
Molecular Formula:C₂₉H₂₈F₃N₃O₃
Molecular Weight:523.555
Hs Code.:

Synonyms:(4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide

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Chemical Property of (4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide

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Technology Process of (4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide

There total 8 articles about (4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1400926-35-3
(4bS,8aR)-4b-benzyl-7-hydroxy-N-(2-methylpyridin-3-yl)-10-oxo-7-(trifluoromethyl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide

: 1400924-77-7
(4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide

: 1400924-76-6
(7aR,11aS)-11a-benzyl-9-hydroxy-N-(2-methylpyridin-3-yl)-6-oxo-9-(trifluoromethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[b,d]azepine-3-carboxamide

Guidance literature:: With sodium azide; methanesulfonic acid; In dichloromethane; at 20 ℃; for 19h;

Reference yield:

: 418772-23-3
(1R,9S,10R)-1-benzyl-5-bromo-10-hydroxy-10-methyl-tricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-13-one1(R)-benzyl-5-bromo-10(R)-hydroxy-10-methyl-tricyclo[7.3.1.0_2,7]trideca-2,4,6-trien-13-one

: 1400924-77-7
(4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide

: 1400924-76-6
(7aR,11aS)-11a-benzyl-9-hydroxy-N-(2-methylpyridin-3-yl)-6-oxo-9-(trifluoromethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[b,d]azepine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium ethanolate / ethanol / 0.5 h / 80 °C / Industry scale

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 15 h / 100 °C / 3102.97 Torr / Inert atmosphere

3.1: hydrogen / 5%-palladium/activated carbon / pyridine; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

4.2: 2 h / -22 - 20 °C

5.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 2 h / 20 °C

6.1: ozone / dichloromethane; methanol / -78 - 20 °C / 206.87 Torr

6.2: PS-PPh₃

7.1: sodium azide; methanesulfonic acid / dichloromethane / 19 h / 20 °C

With sodium azide; methanesulfonic acid; hydrogen; sodium ethanolate; ozone; triethylamine; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 1400926-92-2
(S)-4a-benzyl-7-bromo-4,4a,9,10-tetrahydrophenanthren-2(3H)-one

: 1400924-77-7
(4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide

: 1400924-76-6
(7aR,11aS)-11a-benzyl-9-hydroxy-N-(2-methylpyridin-3-yl)-6-oxo-9-(trifluoromethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[b,d]azepine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 15 h / 100 °C / 3102.97 Torr / Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / pyridine; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

3.2: 2 h / -22 - 20 °C

4.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 2 h / 20 °C

5.1: ozone / dichloromethane; methanol / -78 - 20 °C / 206.87 Torr

5.2: PS-PPh₃

6.1: sodium azide; methanesulfonic acid / dichloromethane / 19 h / 20 °C

With sodium azide; methanesulfonic acid; hydrogen; ozone; triethylamine; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; pyridine; methanol; dichloromethane; toluene;