1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

Base Information

Chemical Name:1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine
CAS No.:1426409-16-6
Molecular Formula:C₁₈H₁₆F₃N₃O
Molecular Weight:347.34
Hs Code.:

Synonyms:1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

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Chemical Property of 1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

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Technology Process of 1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

There total 3 articles about 1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426408-98-1
4,4,5,5-tetramethyl-2-(3-((2,2,2-trifluoroethoxy)methyl)phenyl)-1,3,2-dioxaborolane

: 84819-91-0
dimethyl β-methyl-α-methylenesuccinate

: 1426409-16-6
1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

Guidance literature:: With palladium diacetate; sodium carbonate; tricyclohexylphosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 12h;

Reference yield:

: 1248738-39-7
1-bromo-3-(2,2,2-trifluoroethoxymethyl)benzene

: 1426409-16-6
1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 19 h / 80 °C / Inert atmosphere

2: sodium carbonate; tricyclohexylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 12 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; palladium diacetate; sodium carbonate; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 1426409-16-6
1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere; Reflux

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 19 h / 80 °C / Inert atmosphere

3.1: sodium carbonate; tricyclohexylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 12 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; palladium diacetate; sodium hydride; sodium carbonate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; mineral oil; 2.1: |Suzuki Coupling;