2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline

Base Information

• Chemical Name: 2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline
• CAS No.: 132402-41-6
• Molecular Formula: C₂₇H₂₆N₂O₄S
• Molecular Weight: 474.58
• Mol file: 132402-41-6.mol

Synonyms:2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline

Chemical Property of 2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline

There total 1 articles about 2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

2-benzyloxycarbonylamino-(S)-propioimino ethyl ether (13139-29-2) + benzhydryl (R)-cysteinate nitrate (132402-40-5) → 2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline (132402-41-6)

Guidance literature:

In ethanol; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81482-4

Reference yield: 81.0%

2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline (132402-41-6) → 2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-thiazole (132402-43-8)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81482-4

Reference yield:

2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-(R)-Δ2-thiazoline (132402-41-6) → (S)-1-((S)-2-{[2-((S)-1-Benzyloxycarbonylamino-ethyl)-thiazole-4-carbonyl]-amino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid tert-butyl ester (132402-44-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / activated MnO₂ / CH₂Cl₂ / 4 h / Ambient temperature

2: 35 percent / trifluoroacetic acid / 0.5 h / Ambient temperature

3: dicyclohexylcarbodiimide / CH₂Cl₂ / 5 h / Ambient temperature

4: 75 percent / CH₂Cl₂ / 48 h / Ambient temperature

With manganese(IV) oxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4020(01)81482-4

upstream raw materials:

2-benzyloxycarbonylamino-(S)-propioimino ethyl ether

benzhydryl (R)-cysteinate nitrate

Downstream raw materials:

2-<(S)-1-benzyloxycarbonylaminoethyl>-4-diphenylmethoxycarbonyl-thiazole

2-<(S)-1-benzyloxycarbonylaminoethyl>-4-carboxy-thiazole

(S)-1-((S)-2-{[2-((S)-1-Benzyloxycarbonylamino-ethyl)-thiazole-4-carbonyl]-amino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid tert-butyl ester

(S)-1-((S)-2-{[2-((S)-1-Benzyloxycarbonylamino-ethyl)-thiazole-4-carbonyl]-amino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester