(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone

Base Information

• Chemical Name: (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone
• CAS No.: 1601300-21-3
• Molecular Formula: C₁₄H₁₃F₂N₃O₃
• Molecular Weight: 309.272
• Mol file: 1601300-21-3.mol

Synonyms:(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone

Chemical Property of (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone

There total 3 articles about (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1'-Carbonyl-di-(1,2,4-triazole) (41864-22-6) + 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid (162401-62-9) → (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone (1601300-21-3)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde (151103-09-2) → (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone (1601300-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; aminosulfonic acid / 5 - 20 °C

2: dimethyl sulfoxide / 2 h / 20 °C

With aminosulfonic acid; acetic acid; In dimethyl sulfoxide;

Reference yield:

4-difluoromethoxy-3-hydroxybenzaldehyde (151103-08-1) → (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone (1601300-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / dimethyl sulfoxide / 1 h / 70 °C

1.2: 4 h / 70 °C

2.1: acetic acid; aminosulfonic acid / 5 - 20 °C

3.1: dimethyl sulfoxide / 2 h / 20 °C

With aminosulfonic acid; potassium carbonate; acetic acid; potassium iodide; In dimethyl sulfoxide;

upstream raw materials:

1,1'-Carbonyl-di-(1,2,4-triazole)

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde

Downstream raw materials:

roflumilast