6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one

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Chemical Name:6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one
CAS No.:1256779-56-2
Molecular Formula:C₃₅H₄₁N₇O₂
Molecular Weight:591.756
Hs Code.:

Synonyms:6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one

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Chemical Property of 6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one

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Technology Process of 6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one

There total 10 articles about 6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256780-00-3
2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenylacetonitrile

: 1256779-56-2
6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; at 85 ℃; for 6h; Inert atmosphere;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256779-56-2
6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 12 h / Reflux

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

6.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

7.1: water; lithium hydroxide monohydrate / methanol / 2 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

8.2: 4 h / 20 °C

9.1: trichlorophosphate / 2 h / 100 °C

10.1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 6 h / 85 °C / Inert atmosphere

With lithium hydroxide monohydrate; trimethylsilylazide; ammonium acetate; tetrabutyl ammonium fluoride; water; trimethylaluminum; phosphorus tribromide; sodium hydride; di(n-butyl)tin oxide; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; methanol; n-heptane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1256779-86-8
methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate

: 1256779-56-2
6-butyl-2-methyl-5-[4-{phenyl(1H-tetrazol-5-yl)methoxy}-3,5-dipropylbenzyl]-3-(pyridin-2-yl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

1.2: 14 h / 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2.2: 12 h / Reflux

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

4.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

5.1: water; lithium hydroxide monohydrate / methanol / 2 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

6.2: 4 h / 20 °C

7.1: trichlorophosphate / 2 h / 100 °C

8.1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 6 h / 85 °C / Inert atmosphere

With lithium hydroxide monohydrate; trimethylsilylazide; ammonium acetate; tetrabutyl ammonium fluoride; water; trimethylaluminum; di(n-butyl)tin oxide; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; methanol; n-heptane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;