(E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Base Information

Chemical Name:(E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide
CAS No.:1609084-40-3
Molecular Formula:C₂₈H₂₆F₃NO₇
Molecular Weight:545.512
Hs Code.:

Synonyms:(E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

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Chemical Property of (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Chemical Property:

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Technology Process of (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

There total 7 articles about (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609084-44-7
(3-amino-4,5-dimethoxyphenyl)(3,4,5-trimethoxyphenyl)methanone

: 105919-36-6,120681-07-4
trans-4-(trifluoromethyl)cinnamoyl chloride

: 1609084-40-3
(E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.03.076

Reference yield:

: 1609084-43-6
C₁₈H₁₉NO₈

: 1609084-40-3
(E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; hydrogenchloride / acetic acid; water; ethanol / 1 h / Reflux

2: triethylamine / dichloromethane; tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; iron; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid;
DOI:10.1016/j.bmcl.2014.03.076

Reference yield:

: 1609084-42-5
(3,4-dimethoxy-5-nitrophenyl)(3,4,5-trimethoxyphenyl)methanol

: 1609084-40-3
(E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: dipyridinium dichromate / dichloromethane / 8 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

2: iron; hydrogenchloride / acetic acid; water; ethanol / 1 h / Reflux

3: triethylamine / dichloromethane; tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dipyridinium dichromate; iron; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid;
DOI:10.1016/j.bmcl.2014.03.076