(2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Base Information

Chemical Name:(2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
CAS No.:136010-43-0
Molecular Formula:C₂₀H₃₅N₃O₃S
Molecular Weight:397.582
Hs Code.:

Synonyms:(2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Chemical Property of (2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Technology Process of (2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

There total 2 articles about (2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 136010-42-9
N-(tert-butoxycarbonyl)-4-thiazolylalaninyl amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: 136010-43-0
(2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jm00088a005

Reference yield:

: 119434-75-2,119378-93-7
(S)-3-(4-thiazolyl)-2-tert-butoxycarbonylaminopropanoic acid

: 136010-43-0
(2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 2 steps

1: 90.8 percent / HOBt, DCC / tetrahydrofuran / 5 deg C, 5 min; rt, 18 h

2: 91 percent / HCl / methanol / 17 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1080/00397919608004592

Reference yield: 97.0%

: 618-68-8
2-benzyl-3-phenylpropanoic acid

: 136010-43-0
(2S,3R,4S)-2-<(L-4-thiazolylalanyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: 140903-55-5
(2S,3R,4S)-2-<amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1021/jm00088a005