(R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide

Base Information

Chemical Name:(R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
CAS No.:1280200-56-7
Molecular Formula:C₂₆H₂₉F₃N₂O₂
Molecular Weight:458.524
Hs Code.:

Synonyms:(R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide

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Chemical Property of (R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide

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Technology Process of (R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide

There total 8 articles about (R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1057079-57-8
3-(cyclopropyl)-5-aminobenzotrifluoride

: 1280200-68-1
(R)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxylic acid

: 1280200-56-7
(R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide

Guidance literature:: (R)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxylic acid; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃;

3-(cyclopropyl)-5-aminobenzotrifluoride; In tetrahydrofuran; at 55 ℃;

Reference yield:

: 54962-75-3
[3-bromo-5-(trifluoromethyl)phenyl]amine

: 1280200-56-7
(R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tricyclohexylphosphine; palladium diacetate / toluene; water / 2 h / 100 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran / 0 - 20 °C

2.2: 55 °C

With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; water; toluene;

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 1280200-56-7
(R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 0.75 h / 130 °C

2.1: acetyl chloride / 1 h / 64 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C

4.1: water; lithium hydroxide / methanol / 1 h / 80 °C / sealed vial

4.2: 0.25 h / 20 °C

5.1: brucine / ipa / 80 °C / Resolution of racemate

6.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran / 0 - 20 °C

6.2: 55 °C

With water; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; brucine; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ipa;