5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

Base Information

Chemical Name:5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole
CAS No.:1418297-37-6
Molecular Formula:C₂₁H₁₉F₃N₂O
Molecular Weight:372.39
Hs Code.:

Synonyms:5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

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Chemical Property of 5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

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Technology Process of 5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

There total 6 articles about 5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1085454-04-1
5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carbaldehyde

: triphenyl[4-(trifluoromethoxy)-benzyl]phosphonium bromide

: 1418297-38-7
5-Methyl-1-(4-methylbenzyl)-3-{(Z)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

: 1418297-37-6
5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

Guidance literature:: With sodium ethanolate; In ethanol; at 100 ℃; for 2h;

Reference yield:

: 20577-61-1
methyl 2,4-dioxopentanoate

: 1418297-38-7
5-Methyl-1-(4-methylbenzyl)-3-{(Z)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

: 1418297-37-6
5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 4 h / 90 °C

2: water; sodium hydroxide / ethanol / 70 °C

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

4: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C / Inert atmosphere

5: sodium ethanolate / ethanol / 2 h / 100 °C

With lithium aluminium tetrahydride; oxalyl dichloride; water; sodium ethanolate; acetic acid; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1085454-02-9
[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]methanol

: 1418297-38-7
5-Methyl-1-(4-methylbenzyl)-3-{(Z)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

: 1418297-37-6
5-methyl-1-(4-methylbenzyl)-3-{(E)-2-[4-(trifluoromethoxy)phenyl]vinyl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 2 h / 100 °C

With oxalyl dichloride; sodium ethanolate; In ethanol; dichloromethane; dimethyl sulfoxide;