4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide

Base Information

Chemical Name:4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide
CAS No.:1431616-29-3
Molecular Formula:C₁₇H₁₂F₆N₂O
Molecular Weight:374.285
Hs Code.:

Synonyms:4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide

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Chemical Property of 4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide

Chemical Property:

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Technology Process of 4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide

There total 4 articles about 4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1431616-45-3
4-(1-(trifluoromethyl)cyclopropyl)benzoyl chloride

: 106877-33-2
6-(trifluoromethyl)pyridin-3-amine

: 1431616-29-3
4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 23 ℃;
DOI:10.1021/ml400045j

Reference yield:

: 1418128-91-2
4-((1-trifluoromethyl)cycloprop-1-yl)benzoic acid

: 1431616-29-3
4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 23 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ml400045j

Reference yield:

: 1431616-40-8
3-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-3H-pyrazole

: 1431616-29-3
4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

2: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

3: oxalyl dichloride / dichloromethane

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 23 °C

With n-butyllithium; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; acetonitrile;
DOI:10.1021/ml400045j