1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester
CAS No.:1170701-04-8
Molecular Formula:C₂₀H₁₅Cl₂F₃N₂O₂
Molecular Weight:443.253
Hs Code.:

Synonyms:1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

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Chemical Property of 1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

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Technology Process of 1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

There total 4 articles about 1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 711-33-1
4-trifluoromethyl propiophenone

: 95-92-1
oxalic acid diethyl ester

: 13123-92-7
(2,4-dichlorophenyl)hydrazine

: 1170701-04-8
1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: 4-trifluoromethyl propiophenone; With lithium hexamethyldisilazane; In methyl cyclohexane; at 20 ℃; for 3h;

oxalic acid diethyl ester; In methyl cyclohexane; for 16h;

(2,4-dichlorophenyl)hydrazine; With sulfuric acid; In ethanol; Cooling with ice; Reflux;
DOI:10.1016/j.ejmech.2013.07.054

Reference yield:

: lithium 3-ethoxycarbonyl-2-methyl-3-oxo-1-(4-trifluoromethylphenyl)propan-1-olate

: 5446-18-4
2,4-dichlorophenyl hydrazine hydrochloride

: 1170701-04-8
1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: With sulfuric acid; In ethanol; for 7h; Reflux;

Reference yield:

: 711-33-1
4-trifluoromethyl propiophenone

: 1170701-04-8
1-(2,4-dichlorophenyl)-5-(4-(trifluoromethyl)phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / methyl cyclohexane / 2 h / 15 - 25 °C

1.2: 16 h

2.1: sulfuric acid / ethanol / 7 h / Reflux

With sulfuric acid; lithium hexamethyldisilazane; In ethanol; methyl cyclohexane;