2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid

Base Information

Chemical Name:2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid
CAS No.:1265395-82-1
Molecular Formula:C₂₃H₃₁N₃O₂
Molecular Weight:381.518
Hs Code.:

Synonyms:2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid

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Chemical Property of 2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid

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Technology Process of 2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid

There total 14 articles about 2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1265395-76-3
methyl 2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

: 1265395-82-1
2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid

Guidance literature:: methyl 2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate; With methanol; sodium hydroxide; at 20 ℃; for 96h;

With hydrogenchloride; In water; pH=2 - 3;

Reference yield:

: 615-83-8
2-bromo-pentanoic acid ethyl ester

: 1265395-82-1
2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 21 h / 80 °C

2.2: 0.5 h / 20 °C

3.1: water; chloroacetic acid / 20 h / Reflux

4.1: thionyl chloride / 48 h / 0 °C / Reflux

5.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 115 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 90 °C

7.1: triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / 110 °C / Sealed tube

8.1: sodium hydroxide; methanol / 96 h / 20 °C

8.2: pH 2 - 3

With methanol; thionyl chloride; water; sodium methylate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; N-ethyl-N,N-diisopropylamine; chloroacetic acid; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 162498-52-4
(2,4-dichloro-6-methylpyrimidin-5-yl)acetic acid methyl ester

: 1265395-82-1
2-(4-methyl-2-(3-methylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -78 °C

2.2: 3 h / -15 - 20 °C

3.1: triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / 110 °C / Sealed tube

4.1: sodium hydroxide; methanol / 96 h / 20 °C

4.2: pH 2 - 3

With methanol; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;