(E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine

Base Information

Chemical Name:(E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine
CAS No.:936828-67-0
Molecular Formula:C₁₄H₁₆ClNO₃
Molecular Weight:281.739
Hs Code.:

Synonyms:(E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine

Suppliers and Price of (E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine

There total 4 articles about (E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 106-47-8
4-chloro-aniline

: 71165-16-7
(3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole-4-carbaldehyde

: 936828-67-0
(E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine

Guidance literature:: With magnesium sulfate; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.tet.2007.02.022

Reference yield:

: 53626-11-2
(S)-((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethane-1,2-diol

: 936828-67-0
(E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / NaIO₄; silica / CH₂Cl₂; H₂O / 5 h / 20 °C

2: 96 percent / anhydrous MgSO₄ / CH₂Cl₂ / 15 h / 20 °C

With sodium periodate; silica gel; magnesium sulfate; In dichloromethane; water;
DOI:10.1016/j.tet.2007.02.022

Reference yield:

: 188778-70-3
O⁴,O⁵-isopropylidene-3,6-anhydro-1-deoxy-1-iodo-D-glucitol

: 936828-67-0
(E)-4-chloro-N-(((3aR,4R,6aR)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylene)benzenamine

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / NaH / tetrahydrofuran / 5 h / 20 °C

2: 60 percent / NaOH / tetrahydrofuran; H₂O / 48 h / Heating

3: 82 percent / NaIO₄; silica / CH₂Cl₂; H₂O / 5 h / 20 °C

4: 96 percent / anhydrous MgSO₄ / CH₂Cl₂ / 15 h / 20 °C

With sodium hydroxide; sodium periodate; silica gel; sodium hydride; magnesium sulfate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2007.02.022