4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene

Base Information

Chemical Name:4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene
CAS No.:445039-52-1
Molecular Formula:C₂₁H₁₆F₂O₅S
Molecular Weight:418.418
Hs Code.:

Synonyms:4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene

Chemical Property:

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Technology Process of 4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene

There total 4 articles about 4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 445039-93-0
(3,5-difluorophenyl)(6-(4-methylthiophenyl)(2H-benzo[d]1,3-dioxolan-5-yl))methan-1-ol

: 445039-52-1
4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene

Guidance literature:: With Oxone; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jm030268b

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 445039-52-1
4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / bromine; acetic acid; iodine / CS₂ / 20 °C

2: 88 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium / ethanol / Heating

3: tetrahydrofuran / 2.17 h / 0 - 20 °C

4: aq. oxone / methanol / 2 h / 20 °C

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; iodine; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; carbon disulfide; ethanol; 2: Suzuki coupling / 3: Grignard reaction;
DOI:10.1021/jm030268b

Reference yield:

: 15930-53-7
6-bromo-3,4-methylenedioxybenzaldehyde

: 445039-52-1
4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-methylenedioxy-5-(4-methylsulfonylphenyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium / ethanol / Heating

2: tetrahydrofuran / 2.17 h / 0 - 20 °C

3: aq. oxone / methanol / 2 h / 20 °C

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; methanol; ethanol; 1: Suzuki coupling / 2: Grignard reaction;
DOI:10.1021/jm030268b