(4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane

Base Information

Chemical Name:(4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane
CAS No.:1393593-53-7
Molecular Formula:C₄₆H₅₈N₄O₄
Molecular Weight:730.991
Hs Code.:

Synonyms:(4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane

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Chemical Property of (4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane

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Technology Process of (4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane

There total 3 articles about (4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 110-52-1
1,4-dibromo-butane

: 1393593-52-6
(4S,αR)-4-phenyl-N(5)-(α-methyl-4'-methoxybenzyl)-1,5-diazocan-2-one

: 1393593-53-7
(4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide; In toluene; at 160 ℃; for 0.25h; Inert atmosphere; Sealed tube; Microwave irradiation;
DOI:10.1021/jo3012732

Reference yield:

: 1356849-85-8
(R)-N-(3-chloroprop-1-yl)-N-(α-methyl-4'-methoxybenzyl)amine

: 1393593-53-7
(4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

2.1: sodium azide; sodium iodide / dimethyl sulfoxide / 24 h / 50 °C

3.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C

3.2: 2 h / 50 °C

4.1: triethoxyantimony / toluene / 2 h / Molecular sieve; Reflux

5.1: tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide / toluene / 0.25 h / 160 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With n-butyllithium; sodium azide; triethoxyantimony; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium iodide; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jo3012732

Reference yield:

: 1356849-80-3
methyl (3S,αR)-3-[N-( 3'-chloropropyl)-N-(α-methyl-4''-methoxybenzyl)amino]-3-phenylpropanoate

: 1393593-53-7
(4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide; sodium iodide / dimethyl sulfoxide / 24 h / 50 °C

2.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C

2.2: 2 h / 50 °C

3.1: triethoxyantimony / toluene / 2 h / Molecular sieve; Reflux

4.1: tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide / toluene / 0.25 h / 160 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With sodium azide; triethoxyantimony; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium iodide; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jo3012732