Technology Process of (4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane
There total 3 articles about (4'S,αR,E)-1,4-di[2'-oxo-4'-phenyl-N(5')-α-methyl-4''-methoxybenzyl-1',5'-diazocan-N(1')-yl]butane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide;
In
toluene;
at 160 ℃;
for 0.25h;
Inert atmosphere;
Sealed tube;
Microwave irradiation;
DOI:10.1021/jo3012732
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C
2.1: sodium azide; sodium iodide / dimethyl sulfoxide / 24 h / 50 °C
3.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
3.2: 2 h / 50 °C
4.1: triethoxyantimony / toluene / 2 h / Molecular sieve; Reflux
5.1: tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide / toluene / 0.25 h / 160 °C / Inert atmosphere; Sealed tube; Microwave irradiation
With
n-butyllithium; sodium azide; triethoxyantimony; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium iodide; potassium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jo3012732
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium azide; sodium iodide / dimethyl sulfoxide / 24 h / 50 °C
2.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
2.2: 2 h / 50 °C
3.1: triethoxyantimony / toluene / 2 h / Molecular sieve; Reflux
4.1: tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide / toluene / 0.25 h / 160 °C / Inert atmosphere; Sealed tube; Microwave irradiation
With
sodium azide; triethoxyantimony; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium iodide; potassium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jo3012732
