2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol

Base Information

Chemical Name:2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol
CAS No.:80027-54-9
Molecular Formula:C₂₂H₂₄O₆
Molecular Weight:384.429
Hs Code.:

Synonyms:2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol

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Chemical Property of 2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol

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Technology Process of 2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol

There total 17 articles about 2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 80027-53-8
2-Acetyl-5-hydroxy-8-methoxy-6-(4-methoxy-3-phthalido)-1,2,3,4-tetrahydronaphthalene

: 80027-54-9
2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol

Guidance literature:: With sodium hydroxide; zinc; In water; for 2h; Heating;

Reference yield:

: 41098-99-1
1,2,3,4-tetrahydro-5,8-dimethoxy-4-oxonaphthalene-2-carboxylic acid

: 80027-54-9
2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / HCl / 1.5 h / Heating

2: 63 percent / BCl₃ / CH₂Cl₂ / 0.17 h / Ambient temperature

3: 81 percent / conc.HCl, H₂ / platinum oxide / methanol

4: 82.5 percent / K₂CO₃ / dimethylformamide / 4 h / 80 °C

5: 92 percent / NaOH / H₂O; methanol / 3 h / Heating

6: 77.5 percent / diethyl ether / 4 h / Ambient temperature

7: 91.5 percent / H₂ / Pd-C / ethyl acetate

8: 1.) benzeneboronic acid, propionic acid, 2.) acetic acid / 1.) benzene, reflux, 20 h, 2.) CH₂Cl₂, 2-methylpentane-2,4-diol, room temperature, 20 h

9: 82 percent / Zn, NaOH / H₂O / 2 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; boron trichloride; potassium carbonate; acetic acid; propionic acid; zinc; phenylboronic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 76117-16-3
methyl 1,2,3,4-tetrahydro-5,8-dimethoxy-4-oxonaphthalene-2-carboxylate

: 80027-54-9
2-acetyl-6-(2-carboxy-6-methoxybenzyl)-1,2,3,4-tetrahydro-8-methoxy-5-naphthol

Guidance literature:: Multi-step reaction with 8 steps

1: 63 percent / BCl₃ / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 81 percent / conc.HCl, H₂ / platinum oxide / methanol

3: 82.5 percent / K₂CO₃ / dimethylformamide / 4 h / 80 °C

4: 92 percent / NaOH / H₂O; methanol / 3 h / Heating

5: 77.5 percent / diethyl ether / 4 h / Ambient temperature

6: 91.5 percent / H₂ / Pd-C / ethyl acetate

7: 1.) benzeneboronic acid, propionic acid, 2.) acetic acid / 1.) benzene, reflux, 20 h, 2.) CH₂Cl₂, 2-methylpentane-2,4-diol, room temperature, 20 h

8: 82 percent / Zn, NaOH / H₂O / 2 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; boron trichloride; potassium carbonate; acetic acid; propionic acid; zinc; phenylboronic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;