1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

Base Information

Chemical Name:1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one
CAS No.:1473452-72-0
Molecular Formula:C₂₁H₂₀N₂O₂
Molecular Weight:332.402
Hs Code.:

Synonyms:1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

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Technology Process of 1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

There total 4 articles about 1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1473452-74-2
3-methyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

: 1473452-72-0
1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; for 4h; Reflux;
DOI:10.1016/j.bmcl.2017.02.057

Reference yield:

: 1473452-73-1
1-(2-fluoro-5-nitrophenyl)-3-methyl-6,7-dihydro-2H-isoindol-4(5H)-one

: 1473452-72-0
1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

2: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 9 h / Reflux

With iron; ammonium chloride; caesium carbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1473452-17-3
1-bromo-3-methyl-6,7-dihydro-2H-isoindol-4(5H)-one

: 1473452-72-0
1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 6.5 h / 60 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

3: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 9 h / Reflux

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; caesium carbonate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;