(5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

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Chemical Name:(5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone
CAS No.:1014701-64-4
Molecular Formula:C₂₉H₃₅F₂N₅O₂
Molecular Weight:523.626
Hs Code.:

(5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

Synonyms:(5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

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Chemical Property of (5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

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Technology Process of (5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

There total 12 articles about (5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: C₂₄H₃₁N₅O*4ClH

: 107496-54-8
3,3-difluorocyclobutanecarboxylic acid

: 1014701-64-4
(5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1014702-81-8
(5-benzyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

: 1014701-64-4
(5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium formate / palladium on activated charcoal / methanol / 8 h / Heating / reflux

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 1 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1014702-88-5
C₁₆H₂₃NO₃

: 1014701-64-4
(5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-azetidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hypochlorite; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 4 h / 0 - 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 1 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With hydrogenchloride; sodium hypochlorite; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In 1,4-dioxane; dichloromethane; water;