1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

Base Information

Chemical Name:1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole
CAS No.:222991-29-9
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

1-(2'-tetrahydropyranyl)-2-carbomethoxy-4<sup>(5)</sup>-(3'',5''-dimethoxyphenyl)imidazole

Synonyms:1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

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Chemical Property of 1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

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Technology Process of 1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

There total 3 articles about 1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 188199-81-7
2-carbomethoxy-4⁽⁵⁾-(3',5'-dimethoxyphenyl)imidazole

: 222991-29-9
1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; at 60 ℃; for 10h;
DOI:10.1021/jo981805g

Reference yield:

: 39151-19-4
1-(3,5-dimethoxyphenyl)ethan-1-one

: 222991-29-9
1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / aq. HBr / dimethylsulfoxide / 8 h / 60 - 68 °C

2: 63 percent / NH₄OAc / acetonitrile / 2 h / 0 °C

3: 63 percent / p-TsOH*H₂O / tetrahydrofuran / 10 h / 60 °C

With ammonium acetate; hydrogen bromide; toluene-4-sulfonic acid; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo981805g

Reference yield:

: 188199-78-2
3',5'-dimethoxyphenylglyoxal monohydrate

: 222991-29-9
1-(2'-tetrahydropyranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NH₄OAc / acetonitrile / 2 h / 0 °C

2: 63 percent / p-TsOH*H₂O / tetrahydrofuran / 10 h / 60 °C

With ammonium acetate; toluene-4-sulfonic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo981805g