(E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin

Base Information

• Chemical Name: (E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin
• CAS No.: 1202529-15-4
• Molecular Formula: C₂₆H₂₆N₄O
• Molecular Weight: 410.519
• Mol file: 1202529-15-4.mol

Synonyms:(E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin

Chemical Property of (E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin

There total 7 articles about (E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(Z)-1-isopropyl-5-[1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)propylidene]-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin (1202528-97-9) + 3-Iodoaniline (626-01-7) → (E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin (1202529-15-4)

Guidance literature:

With 3,5-dimethoxyphenol; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 2h;

Reference yield:

(3-iodo-pyridin-2-yl)-methanol (38749-98-3) → (E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin (1202529-15-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 °C / Cooling with ice

1.2: 20 °C / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C

3.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / 100 °C

4.1: 3,5-dimethoxyphenol; potassium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 80 °C

With potassium phosphate; 3,5-dimethoxyphenol; methanesulfonyl chloride; triethylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

3-iodo-pyridine-2-carboxylic acid methyl ester (73841-41-5) → (E)-5-[1-(3-aminophenyl)propylidene]-1-isopropyl-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin (1202529-15-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: calcium chloride; sodium tetrahydroborate; but-1-yne / 1.5 h / 0 °C / Cooling with ice

2.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 °C / Cooling with ice

2.2: 20 °C / Cooling with ice

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C

4.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / 100 °C

5.1: 3,5-dimethoxyphenol; potassium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 80 °C

With sodium tetrahydroborate; potassium phosphate; 3,5-dimethoxyphenol; but-1-yne; methanesulfonyl chloride; triethylamine; calcium chloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

(Z)-1-isopropyl-5-[1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)propylidene]-5,10-dihydro-1H-indazolo[6,5-b]pyrido[3,2-e]oxepin

3-Iodoaniline

(3-iodo-pyridin-2-yl)-methanol

3-iodo-pyridine-2-carboxylic acid methyl ester