1-methylspermidine

Base Information

• Chemical Name: 1-methylspermidine
• CAS No.: 137946-02-2
• Molecular Formula: C₈H₂₁N₃
• Molecular Weight: 159.275
• Mol file: 137946-02-2.mol

Synonyms:1,3-Butanediamine,N1-(4-aminobutyl);1,8-diamino-5-azanonane;N1-(4-aminobutyl)butane-1,3-diamine;1-Methylspermidine;

Chemical Property of 1-methylspermidine

Chemical Property:

• Vapor Pressure: 0.0246mmHg at 25°C
• Boiling Point: 248.2°Cat760mmHg
• Flash Point: 119.3°C
• PSA: 64.07000
• Density: 0.899g/cm³
• LogP: 1.84370

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 1-Methylspermidine, a naturally occurring polyamine, serves various important roles across different fields. In the realm of molecular biology and biochemistry, it plays a crucial role in cell growth, proliferation, and gene expression, making it a valuable tool for studying cellular processes and as a component in cell culture media. In the field of medicine, 1-Methylspermidine has potential applications in cancer research and therapy due to its involvement in cell cycle regulation and DNA stability, making it a target for novel anticancer drug development. Additionally, in agriculture and horticulture, it has been studied for its effects on plant growth and stress tolerance, potentially improving crop yields and plant resilience to adverse conditions. Its versatility highlights its significance in advancing our understanding of cellular biology, its potential in medical treatments, and its potential in agriculture for crop improvement.

Technology Process of 1-methylspermidine

There total 3 articles about 1-methylspermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N8-(benzyloxycarbonyl)-1,8-diamino-5-azanonane (784213-60-1) → 1,8-diamino-5-azanonane (137946-02-2)

Guidance literature:

With hydrogen; palladium; In methanol; acetic acid; atmospheric pressure;

DOI:10.1021/jm050872h

Reference yield:

N1-(carbobenzyloxy)-N4-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane (137945-95-0) → 1,8-diamino-5-azanonane (137946-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 24 h / 2068.6 Torr

2: BH₃*THF / tetrahydrofuran / 1.) reflux, 48 h, 2.) RT, 24 h

With borane-THF; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00082a013

Reference yield:

N1-(3-aminobutyryl)-1,4-diaminobutane (137945-97-2) → 1,8-diamino-5-azanonane (137946-02-2)

Guidance literature:

With borane-THF; In tetrahydrofuran; 1.) reflux, 48 h, 2.) RT, 24 h;

DOI:10.1021/jm00082a013

upstream raw materials:

N¹-(3-aminobutyryl)-1,4-diaminobutane

N⁸-(benzyloxycarbonyl)-1,8-diamino-5-azanonane

N¹-(carbobenzyloxy)-N⁴-<3-<(carbobenzyloxy)amino>butyryl>-1,4-diaminobutane

Refernces

• 1、 Lakanen,Coward,Pegg. "α-Methyl polyamines: Metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines". . p. 724 - 734. Retrieved 2007/10/02.