methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate

Base Information

• Chemical Name: methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate
• CAS No.: 1379520-51-0
• Molecular Formula: C₂₉H₂₄N₂O₇
• Molecular Weight: 512.519
• Mol file: 1379520-51-0.mol

Synonyms:methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate

Chemical Property of methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate

There total 8 articles about methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 4-amino-3-(benzyloxy)benzoate (475215-88-4) + 4-nitro-3-phenylmethoxybenzoic acid (14617-29-9) → methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate (1379520-51-0)

Guidance literature:

With dichlorotriphenylphosphorane; In chloroform; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2011.11.078

Reference yield:

3-hydroxy-4-nitro-benzoic acid (619-14-7) → methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate (1379520-51-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / 65 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; methanol; water / 12 h / 20 °C

3.2: Acidic conditions

4.1: dichlorotriphenylphosphorane / chloroform / 80 °C / Inert atmosphere

With sulfuric acid; potassium carbonate; sodium hydroxide; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.11.078

Reference yield:

methyl 3-hydroxy-4-nitrobenzoate (713-52-0) → methyl 3-(benzyloxy)-4-(3-benzyloxy-4-nitrobenzamido)-benzoate (1379520-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 12 h / 20 °C

2.2: Acidic conditions

3.1: dichlorotriphenylphosphorane / chloroform / 80 °C / Inert atmosphere

With potassium carbonate; sodium hydroxide; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.11.078

upstream raw materials:

methyl 4-amino-3-(benzyloxy)benzoate

4-nitro-3-phenylmethoxybenzoic acid

methyl 3-(benzyloxy)-4-nitrobenzoate

3-hydroxy-4-nitro-benzoic acid