methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate

Base Information

Chemical Name:methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate
CAS No.:898529-40-3
Molecular Formula:C₂₇H₂₄N₂O₈
Molecular Weight:504.496
Hs Code.:

Synonyms:methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate

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Chemical Property of methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate

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Technology Process of methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate

There total 2 articles about methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 898529-39-0
methyl (S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate

: 62-23-7
4-nitro-benzoic acid

: 898529-40-3
methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2006.03.190

Reference yield:

: 898529-38-9
(S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyric acid

: 898529-40-3
methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaHCO₃ / dimethylformamide / 48 h / 20 °C

2: 94 percent / triphenylphosphine; DEAD / tetrahydrofuran / 2 h / 20 °C

With sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2006.03.190

Reference yield:

: 898529-40-3
methyl (R)-2-O-(4-nitrobenzoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxybutyrate

: 2-benzyloxyamino-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaN₃ / methanol / 3 h / 40 °C

2: 2,6-lutidine / CH₂Cl₂ / -78 °C

3: CH₂Cl₂ / 20 °C

With 2,6-dimethylpyridine; sodium azide; In methanol; dichloromethane;
DOI:10.1016/j.tetlet.2006.03.190