N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

Base Information

Chemical Name:N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride
CAS No.:1124219-60-8
Molecular Formula:C₂₅H₂₄F₂N₂O₂*ClH
Molecular Weight:458.936
Hs Code.:

Synonyms:N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

There total 1 articles about N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₂F₂N₂O₄

: 1124219-60-8
N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In chloroform; at 0 ℃;
DOI:10.1021/jm801141f

Reference yield: 89.0%

: 1124219-60-8
N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: chloromethyl 4-[({3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}amino)carbonyl]piperidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejps.2015.03.004

Reference yield:

: 1124219-60-8
N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

: 1124448-32-3
N-{3-[(3',5'-difluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: silver nitrate / acetonitrile / Reflux

3: potassium chloride / acetonitrile; aq. phosphate buffer / 37 °C / pH 7.4

With potassium chloride; silver nitrate; triethylamine; In aq. phosphate buffer; dichloromethane; acetonitrile;
DOI:10.1016/j.ejps.2015.03.004