4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

Base Information

Chemical Name:4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide
CAS No.:1263422-32-7
Molecular Formula:C₂₉H₂₈N₆O₂
Molecular Weight:492.58
Hs Code.:

Synonyms:4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

Suppliers and Price of 4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

There total 5 articles about 4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1263422-34-9
4-(6-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)-imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

: 126747-14-6
4-cyanophenylboronic acid

: 1263422-32-7
4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; at 130 ℃; for 0.166667h;
DOI:10.1021/jm501599u

Reference yield:

: 130290-79-8
4-tetrahydropyranmethylamine

: 1263422-32-7
4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl acetamide / 0.33 h / 130 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 0.33 h / 130 °C

3: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water / 0.17 h / 130 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl acetamide; water; 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1021/jm501599u

Reference yield:

: 6-bromo-3-iodo-N-((tetrahydro-2H-pyran-4-yl)methyl)-imidazo[1,2-a]pyrazin-8-amine

: 1263422-32-7
4-(6-(4-cyanophenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 0.33 h / 130 °C

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water / 0.17 h / 130 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; 1: |Suzuki Coupling / 2: |Suzuki Coupling;
DOI:10.1021/jm501599u