Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester

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Chemical Name:Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester
CAS No.:247578-13-8
Molecular Formula:C₂₆H₃₂N₂O₅
Molecular Weight:452.55
Hs Code.:

Synonyms:Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester

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Chemical Property of Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester

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Technology Process of Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester

There total 4 articles about Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109579-10-4,109579-13-7,144186-19-6
(4S,5R)-N-(((tert)-butyloxy)carbonyl)-5-benzyl-4-hydroxy-2-pyrrolidinone

: 247578-13-8
Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / BH₃SMe₃ / tetrahydrofuran / Heating

2: 46 percent / PPh₃, DIAD / tetrahydrofuran

3: EDCI, HOBT, Et₃N / tetrahydrofuran

With di-isopropyl azodicarboxylate; dimethylsulfide borane complex; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00391-1

Reference yield:

: 109579-09-1
(5S)-5-benzyl-4-hydroxy-1-t-butoxycarbonylpyrrol-2(5H)-one

: 247578-13-8
Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄, AcOH / CH₂Cl₂

2: 39 percent / BH₃SMe₃ / tetrahydrofuran / Heating

3: 46 percent / PPh₃, DIAD / tetrahydrofuran

4: EDCI, HOBT, Et₃N / tetrahydrofuran

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(99)00391-1

Reference yield:

: 247578-10-5
tert-butyl (2S,3S)-2-benzyl-3-hydroxypyrrolidine-1-carboxylate

: 247578-13-8
Acetic acid (2S,3R)-2-benzyl-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / PPh₃, DIAD / tetrahydrofuran

2: EDCI, HOBT, Et₃N / tetrahydrofuran

With di-isopropyl azodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00391-1