hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine

Base Information

• Chemical Name: hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine
• CAS No.: 1338605-29-0
• Molecular Formula: C₄₈H₆₇FN₅O₆P
• Molecular Weight: 860.062

Synonyms:hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine

Chemical Property of hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine

Chemical Property:

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Technology Process of hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine

There total 3 articles about hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

{[3-(hexadecyloxy)propoxy](hydroxy)phosphoryl}methyl tosylate (864068-45-1) + (R,S)-9-[3-fluoro-2-hydroxypropyl]-N6-(4-monomethoxytrityl)adenine (1338605-28-9) → hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)adenine (1338605-29-0)

Guidance literature:

With sodium t-butanolate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)adenine (1338605-29-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 6 h / 100 °C

2: pyridine; trimethylsilyl bromide / 0.25 h

3: sodium t-butanolate / N,N-dimethyl-formamide / 80 °C

With pyridine; trimethylsilyl bromide; sodium hydride; sodium t-butanolate; In N,N-dimethyl-formamide;

Reference yield:

1-(6-amino-9H-purin-9-yl)-3-fluoropropan-2-ol (138870-28-7) → hexadecyloxypropyl (R,S)-9-[3-fluoro-2-(phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)adenine (1338605-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; trimethylsilyl bromide / 0.25 h

2: sodium t-butanolate / N,N-dimethyl-formamide / 80 °C

With pyridine; trimethylsilyl bromide; sodium t-butanolate; In N,N-dimethyl-formamide;

upstream raw materials:

adenine

{[3-(hexadecyloxy)propoxy](hydroxy)phosphoryl}methyl tosylate

(R,S)-9-[3-fluoro-2-hydroxypropyl]-N₆-(4-monomethoxytrityl)adenine

1-(6-amino-9H-purin-9-yl)-3-fluoropropan-2-ol

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