2-Iodo-5-(trifluoromethoxy)benzoic acid

Base Information

Chemical Name:2-Iodo-5-(trifluoromethoxy)benzoic acid
CAS No.:874880-57-6
Molecular Formula:C₈H₄F₃IO₃
Molecular Weight:332.018
Hs Code.:
DSSTox Substance ID:DTXSID701280866

Synonyms:2-IODO-5-(TRIFLUOROMETHOXY)BENZOIC ACID;874880-57-6;SCHEMBL3822429;DTXSID701280866;5-trifluoromethoxy-2-iodobenzoic acid;DB-134944

Suppliers and Price of 2-Iodo-5-(trifluoromethoxy)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Iodo-5-(trifluoromethoxy)benzoic acid

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:331.91573
Heavy Atom Count:15
Complexity:244

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1OC(F)(F)F)C(=O)O)I

Technology Process of 2-Iodo-5-(trifluoromethoxy)benzoic acid

There total 1 articles about 2-Iodo-5-(trifluoromethoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83265-56-9
2-amino-5-(trifluoromethoxy)benzoic acid

: 874880-57-6
5-trifluoromethoxy-2-iodobenzoic acid

Guidance literature:: 2-amino-5-(trifluoromethoxy)benzoic acid; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 0.5h;

With sulfuric acid; potassium iodide; In water; at 10 - 100 ℃; for 2h;

Reference yield:

: 874880-57-6
5-trifluoromethoxy-2-iodobenzoic acid

: 1269520-39-9
methyl 2-iodo-5-(trifluoromethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Inert atmosphere

2: oxalyl dichloride / dichloromethane / 0.5 h / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1039/c3ra42474j