Technology Process of 3,5-Dinitro-benzoic acid (E)-(15R,16S)-15,17-dihydroxy-16-(10-pyren-1-yl-decanoylamino)-heptadec-13-enyl ester
There total 9 articles about 3,5-Dinitro-benzoic acid (E)-(15R,16S)-15,17-dihydroxy-16-(10-pyren-1-yl-decanoylamino)-heptadec-13-enyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: p-toluenesulfonic acid / toluene / 1 h / 20 °C
2.1: 2.20 g / dimethylsulfoxide / 4 h / 20 Torr
3.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: 49 percent / HMPT / tetrahydrofuran; hexane / -78 - -20 °C
4.1: 89 percent / Amberlyst 15 / methanol / 55 h / 20 °C
5.1: 39 percent / Red-Al / diethyl ether; toluene / 24.5 h / 20 °C
6.1: 70 percent / p-toluenesulfonic acid / toluene / Heating
7.1: 100 percent / pyridine / CH2Cl2 / 18 h / 20 °C
8.1: HCl / ethyl acetate / 24 h / 20 °C
9.1: 100 mg / Amberlyst 15 / methanol / 24 h / 20 °C
10.1: 58 percent / tetrahydrofuran / 18 h / 20 °C
With
pyridine; hydrogenchloride; n-butyllithium; Amberlyst 15; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1016/S0009-3084(01)00206-7
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 2.20 g / dimethylsulfoxide / 4 h / 20 Torr
2.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 49 percent / HMPT / tetrahydrofuran; hexane / -78 - -20 °C
3.1: 89 percent / Amberlyst 15 / methanol / 55 h / 20 °C
4.1: 39 percent / Red-Al / diethyl ether; toluene / 24.5 h / 20 °C
5.1: 70 percent / p-toluenesulfonic acid / toluene / Heating
6.1: 100 percent / pyridine / CH2Cl2 / 18 h / 20 °C
7.1: HCl / ethyl acetate / 24 h / 20 °C
8.1: 100 mg / Amberlyst 15 / methanol / 24 h / 20 °C
9.1: 58 percent / tetrahydrofuran / 18 h / 20 °C
With
pyridine; hydrogenchloride; n-butyllithium; Amberlyst 15; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1016/S0009-3084(01)00206-7
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 49 percent / HMPT / tetrahydrofuran; hexane / -78 - -20 °C
2.1: 89 percent / Amberlyst 15 / methanol / 55 h / 20 °C
3.1: 39 percent / Red-Al / diethyl ether; toluene / 24.5 h / 20 °C
4.1: 70 percent / p-toluenesulfonic acid / toluene / Heating
5.1: 100 percent / pyridine / CH2Cl2 / 18 h / 20 °C
6.1: HCl / ethyl acetate / 24 h / 20 °C
7.1: 100 mg / Amberlyst 15 / methanol / 24 h / 20 °C
8.1: 58 percent / tetrahydrofuran / 18 h / 20 °C
With
pyridine; hydrogenchloride; n-butyllithium; Amberlyst 15; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0009-3084(01)00206-7
