2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

Base Information

Chemical Name:2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine
CAS No.:119898-75-8
Molecular Formula:C₃₁H₃₀Cl₂N₄O₅
Molecular Weight:609.509
Hs Code.:

Synonyms:2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

Suppliers and Price of 2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

Chemical Property:

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Technology Process of 2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

There total 6 articles about 2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 119898-70-3
5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-mesyl-2',3'-secoinosine

: 119898-75-8
2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 3h;
DOI:10.1016/S0040-4020(01)89829-X

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 119898-75-8
2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / pyridine / 96 h / 15 °C

2: 91 percent / sodium periodate / acetone; H₂O / 24 h / Ambient temperature; dark

3: 66 percent / sodium borohydride / ethanol; H₂O / Ambient temperature; pH = 7

4: 85 percent / pyridine / 0 °C

5: 97 percent / LiCl / dimethylformamide / 3 h / 100 °C

With sodium tetrahydroborate; sodium periodate; lithium chloride; In pyridine; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)89829-X

Reference yield:

: 119898-59-8
9-[(2R,3R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3,4-dihydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

: 119898-75-8
2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / sodium periodate / acetone; H₂O / 24 h / Ambient temperature; dark

2: 66 percent / sodium borohydride / ethanol; H₂O / Ambient temperature; pH = 7

3: 85 percent / pyridine / 0 °C

4: 97 percent / LiCl / dimethylformamide / 3 h / 100 °C

With sodium tetrahydroborate; sodium periodate; lithium chloride; In pyridine; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)89829-X