(2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide

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Chemical Name:(2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide
CAS No.:1625677-38-4
Molecular Formula:C₃₁H₃₆N₈O₃
Molecular Weight:568.679
Hs Code.:

Synonyms:(2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide

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Chemical Property of (2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide

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Technology Process of (2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide

There total 8 articles about (2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1429497-81-3
8-(3-aminophenyl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

: (E)-4-(dimethylamino)but-2-enoyl chloride hydrochloride salt

: 1625677-38-4
(2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 1584151-29-0
tert-butyl (3-(2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

: 1625677-38-4
(2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide

Guidance literature:: Multi-step reaction with 4 steps

1: peracetic acid / dichloromethane; acetic acid / 0 °C

2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 21 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

With peracetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetic acid; tert-butyl alcohol;

Reference yield:

: 1625677-95-3
tert-butyl (3-(2-(methylsulfinyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

: 1625677-38-4
(2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 21 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;