p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

Base Information

Chemical Name:p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate
CAS No.:92838-75-0
Molecular Formula:C₅₂H₄₆N₅O₁₅P
Molecular Weight:1011.94
Hs Code.:

p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

Synonyms:p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

Suppliers and Price of p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

There total 12 articles about p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76899-07-5,78963-47-0,78963-48-1,78963-60-7,80951-41-3,81275-02-7,85647-75-2,85954-95-6,92217-74-8,104527-11-9,76855-69-1
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one

: 92838-75-0
p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / boron trifluoride etherate / CH₂Cl₂ / 15 h / Ambient temperature

2: 650 mg / m-chloroperbenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

3: 77 percent / dimethylformamide / 15 h / Ambient temperature

4: 1.) H₂; 2.) N,N-diisopropylethylamine / 1.) PtO₂ / 1.) glacial AcOH, 1 atm, 5 h; 2.) CH₂Cl₂, roomtemp.

5: 66 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

6: 90 percent / boron trifluoride etherate / acetonitrile / 0.3 h

7: 66 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.5 h

8: triethylamine / benzene / 0.08 h / 40 °C

9: 1.) 2,6-lutidine, thionyl chloride; 2.) 2,6-lutidine / 1.) THF, -20 deg C, 30 min; 2.) dioxane, roomtemp., 3 h then 40 deg C, 13 h

With 2,6-dimethylpyridine; dmap; thionyl chloride; boron trifluoride diethyl etherate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; platinum(IV) oxide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1246/bcsj.59.1363

Reference yield:

: 92838-69-2,96613-74-0,96613-75-1
(3S,4R)-4-(3-cyano-2-hydroxypropyl)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-2-azetidinone

: 92838-75-0
p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) H₂; 2.) N,N-diisopropylethylamine / 1.) PtO₂ / 1.) glacial AcOH, 1 atm, 5 h; 2.) CH₂Cl₂, roomtemp.

2: 66 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

3: 90 percent / boron trifluoride etherate / acetonitrile / 0.3 h

4: 66 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.5 h

5: triethylamine / benzene / 0.08 h / 40 °C

6: 1.) 2,6-lutidine, thionyl chloride; 2.) 2,6-lutidine / 1.) THF, -20 deg C, 30 min; 2.) dioxane, roomtemp., 3 h then 40 deg C, 13 h

With 2,6-dimethylpyridine; dmap; thionyl chloride; boron trifluoride diethyl etherate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; platinum(IV) oxide; In dichloromethane; acetonitrile; benzene;
DOI:10.1246/bcsj.59.1363

Reference yield:

: 80391-20-4,96613-72-8,96613-73-9
(3S,4R)-4-(2,3-epoxypropyl)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-2-azetidinone

: 92838-75-0
p-nitrobenzyl 2-<(3S,4R)-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-3-<(R)-1-(p-nitrobenzylocycarbonyloxy)ethyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / dimethylformamide / 15 h / Ambient temperature

2: 1.) H₂; 2.) N,N-diisopropylethylamine / 1.) PtO₂ / 1.) glacial AcOH, 1 atm, 5 h; 2.) CH₂Cl₂, roomtemp.

3: 66 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

4: 90 percent / boron trifluoride etherate / acetonitrile / 0.3 h

5: 66 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.5 h

6: triethylamine / benzene / 0.08 h / 40 °C

7: 1.) 2,6-lutidine, thionyl chloride; 2.) 2,6-lutidine / 1.) THF, -20 deg C, 30 min; 2.) dioxane, roomtemp., 3 h then 40 deg C, 13 h

With 2,6-dimethylpyridine; dmap; thionyl chloride; boron trifluoride diethyl etherate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; platinum(IV) oxide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1246/bcsj.59.1363