2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile

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Chemical Name:2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile
CAS No.:1414358-05-6
Molecular Formula:C₃₀H₂₇FN₆O₂
Molecular Weight:522.582
Hs Code.:

Synonyms:2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile

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Chemical Property of 2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile

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Technology Process of 2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile

There total 4 articles about 2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1414358-08-9
5-(2-fluoro-4-phenoxy-phenyl)-7-pyrrolidin-2-ylmethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

: 98895-60-4
2-cyano-3-cyclopropyl-acrylic acid

: 1414358-05-6
2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1414358-06-7
2-(4-amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-ylmethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1414358-05-6
2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 90 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: (3-fluoro-4-phenoxyphenyl)boronic acid

: 1414358-05-6
2-{2-[4-amino-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-ylmethyl]pyrrolidine-1-carbonyl}-3-cyclopropylacrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 90 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; water;