ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

Base Information

Chemical Name:ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate
CAS No.:1380347-58-9
Molecular Formula:C₃₁H₃₃N₃O₅S₂
Molecular Weight:591.752
Hs Code.:

Synonyms:ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

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Chemical Property of ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

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Technology Process of ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

There total 8 articles about ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₇N₃O₆S₂

: 1380347-58-9
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: 494224-49-6
(R)-ethyl 4-(tert-butoxycarbonylamino)-5-oxopentanoate

: 1380347-58-9
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1.08 h / 20 °C / Inert atmosphere

2.2: 0.08 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 6 h / 20 °C / Inert atmosphere

4.1: tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere

5.1: sodium tris(acetoxy)borohydride / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; borane-THF; sodium tris(acetoxy)borohydride; sodium hydride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: 1380347-57-8
ethyl (4R,5E,7S)-8-(3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl)-7-hydroxy-4-((tert-butyloxycarbonyl)amino)-5-octenoate

: 1380347-58-9
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; ethanol / 6 h / 20 °C / Inert atmosphere

2: tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.04.008