5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

Base Information

Chemical Name:5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine
CAS No.:1011476-63-3
Molecular Formula:C₂₃H₂₇N₃O₂
Molecular Weight:377.486
Hs Code.:

Synonyms:5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

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Chemical Property of 5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

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Technology Process of 5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

There total 6 articles about 5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1011476-62-2
6-isobutyl-5-methyl-nicotinic acid N'-(4-allyloxy-3,5-dimethyl-benzoyl)-hydrazide

: 1011476-63-3
5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; at 110 ℃; for 0.1h; Microwave irradiation;

Reference yield:

: 1011476-39-3
5-methyl-6-(2-methylpropenyl)nicotinic acid ethyl ester

: 1011476-63-3
5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 15 h / 20 °C / 760.05 Torr

2: hydrogenchloride; water / 24 h / 65 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 16 h / 0 °C

4: Burgess Reagent / tetrahydrofuran / 0.1 h / 110 °C / Microwave

With hydrogenchloride; Burgess Reagent; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 408539-00-4
4-allyloxy-3,5-dimethyl-benzoic acid chloride

: 1011476-63-3
5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / tetrahydrofuran; dichloromethane / 15 h / 0 - 20 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 16 h / 0 °C

3: Burgess Reagent / tetrahydrofuran / 0.1 h / 110 °C / Microwave

With Burgess Reagent; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; dichloromethane;