4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid

Base Information

• Chemical Name: 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid
• CAS No.: 1190848-17-9
• Molecular Formula: C₂₄H₂₇NO₄
• Molecular Weight: 393.483

Synonyms:4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid

Chemical Property of 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid

Chemical Property:

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Technology Process of 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid

There total 9 articles about 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoate (1190848-47-5) → 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid (1190848-17-9)

Guidance literature:

With potassium hydroxide; In methanol; water; for 2h; Reflux;

DOI:10.1016/j.bmcl.2014.02.037

Reference yield: 81.0%

→ 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid (1190848-17-9)

Guidance literature:

Reference yield:

2,5-dimethyl-2,5-hexanediol (110-03-2) → 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoic acid (1190848-17-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.75 h / 20 °C / Reflux

3.1: aluminum (III) chloride / dichloromethane / 0.58 h / 20 °C / Reflux

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C

4.2: 5 h / 20 °C

5.1: potassium hydroxide / water; methanol / 2 h / Reflux

With hydrogenchloride; aluminum (III) chloride; n-butyllithium; potassium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 2.1: |Friedel-Crafts Alkylation / 3.1: |Friedel-Crafts Acylation / 4.2: |Wittig Olefination;

DOI:10.1016/j.bmcl.2014.02.037

upstream raw materials:

methyl 4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)-2-nitrobenzoate

methyl 4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)-2-nitrobenzoate

2,5-dimethyl-2,5-hexanediol

2,5-dichloro-2,5-dimethyl hexane

Downstream raw materials:

2-[¹⁸F]fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

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