N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester

Base Information

Chemical Name:N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester
CAS No.:141437-90-3
Molecular Formula:C₂₃H₂₈N₂O₃S₂
Molecular Weight:444.619
Hs Code.:

Synonyms:N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester

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Chemical Property of N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester

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Technology Process of N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester

There total 4 articles about N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 141437-89-0
(2-Acetylsulfanylmethyl-3-phenyl-propionylamino)-thioacetic acid S-((S)-2-tert-butoxycarbonylamino-3-phenyl-propyl) ester

: 141437-90-3
N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1021/jm00091a016

Reference yield:

: 141437-85-6,1217604-63-1
(S)-tert-butyl (1-mercapto-3-phenylpropan-2-yl)carbamate

: 141437-90-3
N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

2: 98 percent / CF₃COOH / CH₂Cl₂ / 4 h / 0 - 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jm00091a016

Reference yield:

: 122818-32-0
(S)-2-<(tert-Butoxycarbonyl)amino>-3-phenylpropyl thioacetate

: 141437-90-3
N-<2-<(acetylthio)methyl>-3-phenylpropanoyl>glycine S-(2-amino-3-phenylpropyl) thioester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / 1 M NaOH / ethanol / 3 h / 0 - 20 °C

2: 61 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

3: 98 percent / CF₃COOH / CH₂Cl₂ / 4 h / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1021/jm00091a016