((3,4-DICHLOROPHENYL)AMINO)-N-(4-PYRIDYLCARBONYLAMINO)FORMAMIDE

Base Information

• Chemical Name: ((3,4-DICHLOROPHENYL)AMINO)-N-(4-PYRIDYLCARBONYLAMINO)FORMAMIDE
• CAS No.: 304883-43-0
• Molecular Formula: C₁₃H₁₀Cl₂N₄O₂
• Molecular Weight: 325.154
• Mol file: 304883-43-0.mol

Synonyms:N-(3,4-dichlorophenyl)-2-isonicotinoylhydrazinecarboxamide

Chemical Property of ((3,4-DICHLOROPHENYL)AMINO)-N-(4-PYRIDYLCARBONYLAMINO)FORMAMIDE

Chemical Property:

Purity/Quality:

((3,4-Dichlorophenyl)amino)-N-(4-pyridylcarbonylamino)formamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((3,4-DICHLOROPHENYL)AMINO)-N-(4-PYRIDYLCARBONYLAMINO)FORMAMIDE

There total 2 articles about ((3,4-DICHLOROPHENYL)AMINO)-N-(4-PYRIDYLCARBONYLAMINO)FORMAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoniazid (54-85-3,7640-37-1) + 3,4-dichlorophenylisocyanate (102-36-3) → N-(3,4-dichlorophenyl)-2-isonicotinoylhydrazinecarboxamide (304883-43-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.3390/molecules19043851

Reference yield:

m,p-dichloroaniline (95-76-1) → N-(3,4-dichlorophenyl)-2-isonicotinoylhydrazinecarboxamide (304883-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: dichloromethane / 0.5 h / 20 °C

With triethylamine; In dichloromethane;

DOI:10.3390/molecules19043851

Reference yield: 33.0%

N-(3,4-dichlorophenyl)-2-isonicotinoylhydrazinecarboxamide (304883-43-0) → N-(3,4-dichlorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amine

Guidance literature:

N-(3,4-dichlorophenyl)-2-isonicotinoylhydrazinecarboxamide; With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine; In acetonitrile; at 20 ℃; for 0.0833333h;

With triethylamine; In acetonitrile; at 0 ℃; for 0.5h;

DOI:10.3390/molecules19043851

upstream raw materials:

isoniazid

3,4-dichlorophenylisocyanate

m,p-dichloroaniline