N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide

Base Information

Chemical Name:N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide
CAS No.:73168-77-1
Molecular Formula:C₂₀H₂₃NO₆
Molecular Weight:373.406
Hs Code.:

Synonyms:N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide

Chemical Property:

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Technology Process of N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide

There total 13 articles about N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4697-59-0
7,8-dimethoxyisochroman-3-one

: 1484-85-1
3,4-methylenedioxyphenylethylamine

: 73168-77-1
N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide

Guidance literature:: In ethanol; for 14h; Reflux;
DOI:10.1016/j.bmc.2012.12.016

Reference yield:

: 65495-21-8
N,N-dimethyl-3,4-dimethoxybenzylamine

: 73168-77-1
N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-BuLi / 1) ether, 0 deg C, 1 h; 2) 8 h

2: ethyl chloroformate, NaHCO₃ / benzene / 0.25 h

3: dimethylformamide / 20 h

4: 1) KOH; 2) HCl / 1) methanol, water, reflux, 1.5 h; 2) water, 2 h

5: 84 percent / ethanol / 6 h / Heating

With hydrogenchloride; potassium hydroxide; n-butyllithium; chloroformic acid ethyl ester; sodium hydrogencarbonate; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)91915-5

Reference yield:

: (6-Chloromethyl-2,3-dimethoxy-phenyl)-methanol

: 73168-77-1
N-<2-(3,4-methylenedioxyphenyl)ethyl>(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 20 h

2: 1) KOH; 2) HCl / 1) methanol, water, reflux, 1.5 h; 2) water, 2 h

3: 84 percent / ethanol / 6 h / Heating

With hydrogenchloride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91915-5