2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester

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Chemical Name:2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester
CAS No.:147961-18-0
Molecular Formula:C₃₇H₃₇ClN₂O₄S
Molecular Weight:641.231
Hs Code.:

Synonyms:2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester

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Chemical Property of 2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester

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Technology Process of 2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester

There total 5 articles about 2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155143-17-2
ethyl <1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>acetate

: 147961-18-0
2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

2: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

3: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: [5-Allyloxy-3-tert-butylsulfanyl-1-(4-chloro-benzyl)-1H-indol-2-yl]-acetic acid ethyl ester

: 147961-18-0
2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

2: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

4: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: 1-(4-chlorobenzyl)-1-(4-allyloxy phenyl)hydrazine hydrochloride

: 147961-18-0
2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AcONa, AcOH / toluene / 1.5 h / 70 °C

2: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

3: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

4: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

5: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

With lithium aluminium tetrahydride; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00034a013