Technology Process of (1S,2R,8aS)-1,2-bis(benzyloxy)octahydroindolizine
There total 8 articles about (1S,2R,8aS)-1,2-bis(benzyloxy)octahydroindolizine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen; trifluoroacetic acid;
In
methanol;
at 20 ℃;
for 24h;
under 3800.26 Torr;
DOI:10.1016/j.tet.2011.12.063
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere
2: carbon tetrabromide; triethylamine; triphenylphosphine / dichloromethane / 2 h / 0 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
4: triethylamine / dichloromethane / 3 h / 0 °C
5: palladium 10% on activated carbon; hydrogen; trifluoroacetic acid / methanol / 24 h / 20 °C / 3800.26 Torr
With
carbon tetrabromide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2011.12.063
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
2: triethylamine / dichloromethane / 3 h / 0 °C
3: palladium 10% on activated carbon; hydrogen; trifluoroacetic acid / methanol / 24 h / 20 °C / 3800.26 Torr
With
palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2011.12.063
