(3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone

Base Information

Chemical Name:(3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone
CAS No.:104380-28-1
Molecular Formula:C₄₄H₄₅NO₇Si
Molecular Weight:727.929
Hs Code.:

Synonyms:(3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone

Suppliers and Price of (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone

There total 7 articles about (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86258-97-1
(3S,4S)-4-carboxy-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-2-azetidinone

: 104380-28-1
(3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / 98percent aq. H₂SO₄ / 3 h / 65 °C

2: 88 percent / tetrahydrofuran / 1 h / 0 - 5 °C

3: 100 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 12 h / 0 - 20 °C

4: 89 percent / SOCl₂, pyridine / toluene / 5 h / 20 - 30 °C

5: 95 percent / Cl₂ / ethyl acetate; CCl₄ / 1 h / Ambient temperature

6: 79 percent / Cu₂O, p-toluenesulfonic acid monohydrate, water / dimethylsulfoxide / 2 h / 50 - 55 °C

7: 67 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

With pyridine; 1H-imidazole; copper(I) oxide; dmap; thionyl chloride; sulfuric acid; water; chlorine; toluene-4-sulfonic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.1098

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 104380-28-1
(3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 12 h / 0 - 20 °C

2: 89 percent / SOCl₂, pyridine / toluene / 5 h / 20 - 30 °C

3: 95 percent / Cl₂ / ethyl acetate; CCl₄ / 1 h / Ambient temperature

4: 79 percent / Cu₂O, p-toluenesulfonic acid monohydrate, water / dimethylsulfoxide / 2 h / 50 - 55 °C

5: 67 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

With pyridine; 1H-imidazole; copper(I) oxide; dmap; thionyl chloride; water; chlorine; toluene-4-sulfonic acid; In tetrachloromethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.1098

Reference yield:

: 104362-86-9
(3S,4S)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-(1-hydroxy-1-methylethyl)-2-azetidinone

: 104380-28-1
(3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-diphenylmethylsilyloxymethylethenyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 12 h / 0 - 20 °C

2: 89 percent / SOCl₂, pyridine / toluene / 5 h / 20 - 30 °C

3: 95 percent / Cl₂ / ethyl acetate; CCl₄ / 1 h / Ambient temperature

4: 79 percent / Cu₂O, p-toluenesulfonic acid monohydrate, water / dimethylsulfoxide / 2 h / 50 - 55 °C

5: 67 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

With pyridine; 1H-imidazole; copper(I) oxide; dmap; thionyl chloride; water; chlorine; toluene-4-sulfonic acid; In tetrachloromethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.1098