1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide
• CAS No.: 1426541-57-2
• Molecular Formula: C₁₁H₁₀N₄O₄
• Molecular Weight: 262.225
• Mol file: 1426541-57-2.mol

Synonyms:1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide

Chemical Property of 1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide

There total 1 articles about 1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C13H13N3O5 (1190305-98-6) → 1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide (1426541-57-2)

Guidance literature:

With ammonia; In water; at 20 ℃; for 24.5h;

DOI:10.1021/jm400068e

Reference yield: 76.0%

1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide (1426541-57-2) → 1-(4-methoxyphenyl)-4-nitropyrazole-3-carbonitrile (1426541-59-4)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 0.05h; Microwave irradiation;

DOI:10.1021/jm400068e

Reference yield:

1-(4-methoxyphenyl)-4-nitro-pyrazole-3-carboxamide (1426541-57-2) → C20H17N5O2 (1426541-47-0)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / 0.05 h / 120 °C / Microwave irradiation

2: cyclohexene; palladium 10% on activated carbon / ethanol / 0.17 h / 150 °C / Microwave irradiation

3: ammonium acetate / 0.42 h / 150 °C / Microwave irradiation

4: pyridine / dichloromethane / 24 h / Reflux

With pyridine; palladium 10% on activated carbon; ammonium acetate; cyclohexene; trichlorophosphate; In ethanol; dichloromethane;

DOI:10.1021/jm400068e

upstream raw materials:

C₁₃H₁₃N₃O₅

Downstream raw materials:

C₁₅H₁₅N₅O₂

C₂₀H₁₇N₅O₂

C₂₁H₁₉N₅O₂

C₁₈H₁₅N₅O₃