(3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline
CAS No.:1380538-96-4
Molecular Formula:C₁₇H₁₈INO₂S
Molecular Weight:427.306
Hs Code.:

Synonyms:(3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about (3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-methylbenzenesulfonate {(3S)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-yl}methyl ester

: 1380538-96-4
(3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium iodide; In acetonitrile; at 100 ℃; for 5h; Microwave irradiation;

Reference yield:

: 81097-20-3
N-(2-allyl-benzyl)-4-methyl-benzenesulfonamide

: 1380538-96-4
(3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline

: (R)-3-(iodomethyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With 2-iodo-propane; manganese(IV) oxide; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In α,α,α-trifluorotoluene; at 105 ℃; for 11h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1002/anie.201109044

Reference yield:

: 18881-17-9,62855-02-1,62928-94-3,63006-93-9
(S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

: 1380538-96-4
(3S)-3-(iodomethyl)-2-[(4-methylphenyl)sulphonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: sodium iodide / acetonitrile / 5 h / 100 °C / Microwave irradiation

With triethylamine; sodium iodide; In dichloromethane; acetonitrile;