2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one

Base Information

• Chemical Name: 2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one
• CAS No.: 140173-02-0
• Molecular Formula: C₂₂H₁₆O₃
• Molecular Weight: 328.367
• Mol file: 140173-02-0.mol

Synonyms:2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one

Chemical Property of 2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one

There total 5 articles about 2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(p-anisyl)-4-ethoxyacenaphth<4,5-bc>oxepinium perchlorate → 2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one (140173-02-0)

Guidance literature:

With sodium acetate; In acetic anhydride; for 0.2h;

Reference yield:

1-(6-aminoacenaphthen-5-yl)ethanone (5209-01-8) → 2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one (140173-02-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 70 percent / conc. H₂SO₄, sodium nitrite / H₂O / 0.33 h / 0 °C

2: 64 percent / pyridine / 1 h / 0 °C

3: 88 percent / LiH / dimethylsulfoxide / 0.83 h / 70 °C

4: 80 percent / 72percent HClO₄ / a) 40 min, b) 80 deg C, 7 min

5: 100 percent / CH₃COONa / acetic anhydride / 0.2 h

With pyridine; perchloric acid; sulfuric acid; sodium acetate; lithium hydride; sodium nitrite; In water; acetic anhydride; dimethyl sulfoxide;

Reference yield:

5-Hydroxy-6-(p-methoxybenzoylacetyl)acenaphthene (140172-92-5) → 2-(methoxyphenyl)-7,8-dihydro-4H-acenaphth[5,6-bc]oxepin-4-one (140173-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 72percent HClO₄ / a) 40 min, b) 80 deg C, 7 min

2: 100 percent / CH₃COONa / acetic anhydride / 0.2 h

With perchloric acid; sodium acetate; In acetic anhydride;

upstream raw materials:

1-(6-aminoacenaphthen-5-yl)ethanone

5-Hydroxy-6-(p-methoxybenzoylacetyl)acenaphthene

4-anisoyloxy-5-acetylacenaphthene

1-(6-hydroxyacenaphthen-5-yl)ethanone

Downstream raw materials:

2-(methoxyphenyl)-4H-acenaphth[5,6-bc]oxepin-4-one