(4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

Base Information

Chemical Name:(4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone
CAS No.:876954-45-9
Molecular Formula:C₂₆H₄₆O₃Si
Molecular Weight:434.735
Hs Code.:

Synonyms:(4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

Suppliers and Price of (4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

There total 8 articles about (4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 876954-55-1
(2S,4R,5S,6S,8R)-9-benzyloxy-2,5-di(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

: 876954-45-9
(4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

Guidance literature:: With samarium diiodide; In tetrahydrofuran; methanol; at 0 ℃; for 0.166667h;
DOI:10.1021/ol052900w

Reference yield:

: 2-(tert-butyl-dimethyl-silanyloxy)-hexan-3-one

: 876954-45-9
(4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: (i-PrO)TiCl₃; i-Pr₂NEt / CH₂Cl₂ / 1.5 h / -78 °C

1.2: 85 percent / CH₂Cl₂ / 2 h / -78 °C

2.1: 92 percent / 2,6-lutidine / CH₂Cl₂ / 5 h / 0 °C

3.1: 92 percent / SmI₂ / tetrahydrofuran; methanol / 0.17 h / 0 °C

With 2,6-dimethylpyridine; samarium diiodide; titanium(IV) trichloride isopropoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol052900w

Reference yield:

: 876954-47-1
(2S,4R,5S,6S,8R)-9-benzyloxy-2-(tert-butyldimethylsilyloxy)-4-ethyl-5-hydroxy-6,8-dimethyl-3-nonanone

: 876954-45-9
(4R,5S,6S,8R)-9-benzyloxy-5-(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 2,6-lutidine / CH₂Cl₂ / 5 h / 0 °C

2: 92 percent / SmI₂ / tetrahydrofuran; methanol / 0.17 h / 0 °C

With 2,6-dimethylpyridine; samarium diiodide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol052900w