2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester
CAS No.:80532-40-7
Molecular Formula:C₂₆H₃₆O₅Si
Molecular Weight:456.654
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester

Chemical Property:

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Technology Process of 2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester

There total 1 articles about 2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80532-39-4
2,2-Dimethyl-propionic acid (Z)-(S)-5-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-pent-3-enyl ester

: 80581-28-8
2,2-Dimethyl-propionic acid (R)-2-[(2R,3S)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester

: 80532-40-7
2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -23 ℃; Product distribution; other allylic alcohols;
DOI:10.1021/ja00368a040

Reference yield:

: 80532-40-7
2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester

: 5346-78-1,5401-55-8,6330-69-4,7208-42-6,26674-23-7,74033-71-9,85761-13-3,13437-68-8
penta-O-acetyl-xylitol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 0.1 N NaOH, MeOH, 2.) camphorsulfonic acid, MeC(OMe)2Me, 3.) (n-Bu)4NF

2: 1.) Py, 2.) AlCl₃ / 1.) THF, -23 deg C to room temperature, 2.) Et₂O, -23 deg C

3: 1.) TFA, H₂O, 2.) NaOH, H₂O, 3.) Py

With pyridine; methanol; sodium hydroxide; aluminium trichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; water; 2,2-dimethoxy-propane; trifluoroacetic acid;
DOI:10.1021/ja00368a040

Reference yield:

: 80532-40-7
2,2-Dimethyl-propionic acid (R)-2-[(2S,3R)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-hydroxy-ethyl ester

: 80581-27-7
(S)-3-Benzyl-4-[(R)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 0.1 N NaOH, MeOH, 2.) camphorsulfonic acid, MeC(OMe)2Me, 3.) (n-Bu)4NF

2: 1.) (i-Pr)2(Et)N, 2.) t-BuOK / 1.) C₆H₆, 50 deg C, 2.) THF, -10 deg C -> 0 deg C

With methanol; sodium hydroxide; camphor-10-sulfonic acid; potassium tert-butylate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; 2,2-dimethoxy-propane;
DOI:10.1021/ja00368a040