2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide

Base Information

• Chemical Name: 2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide
• CAS No.: 82299-54-5
• Molecular Formula: C₁₃H₁₉BrMgO₂
• Molecular Weight: 311.502
• Mol file: 82299-54-5.mol

Synonyms:2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide

Chemical Property of 2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide

There total 1 articles about 2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,5-dimethoxy-3,4,6-trimethyl-phenyl)-acetic acid (500886-73-7) → 2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide (82299-54-5)

Guidance literature:

DOI:10.1039/c39820000205

Reference yield:

2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide (82299-54-5) → Tocopherol (59-02-9,18920-62-2)

Guidance literature:

Multi-step reaction with 7 steps

1: tetrahydrofuran / -30 °C

2: Ce(NH₄)2(NO₃)6 / acetonitrile; H₂O

3: H(+)

4: H₂ / Pd-C / Ambient temperature

5: K₂CO₃ / dimethylformamide

6: HIO₄ / tetrahydrofuran

With ammonium cerium(IV) nitrate; hydrogen; hydrogen cation; potassium carbonate; periodic acid; palladium on activated charcoal; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c39820000205

Reference yield:

2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide (82299-54-5) → 2-[(3R,7R,11R)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione (7559-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2,4-di-tert-butyl-6-({[(1R,2R)-2-(dimethylamino)cyclohexyl](methyl)amino}methyl)phenol / toluene / 0.08 h / 20 °C / Schlenk technique

1.2: 0.5 h / -78 °C / Schlenk technique

2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 20 °C

With ammonium cerium (IV) nitrate; 2,4-di-tert-butyl-6-({[(1R,2R)-2-(dimethylamino)cyclohexyl](methyl)amino}methyl)phenol; In water; toluene; acetonitrile;

DOI:10.1039/c7ob00751e

upstream raw materials:

(2,5-dimethoxy-3,4,6-trimethyl-phenyl)-acetic acid

Downstream raw materials:

(+) (S)-6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-carbaldhyde

(1S,2S)-1-((S)-6-Benzyloxy-2,5,7,8-tetramethyl-chroman-2-yl)-propane-1,2-diol

Tocopherol

2-[(3R,7R,11R)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione