3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane

Base Information

• Chemical Name: 3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane
• CAS No.: 914673-95-3
• Molecular Formula: C₄₈H₃₅IN₂O₄S₂
• Molecular Weight: 894.853
• Mol file: 914673-95-3.mol

Synonyms:3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane

Chemical Property of 3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane

There total 16 articles about 3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-{[5-tert-butylsulfanyl-3-(2',3'-dinitro-4'-trimethylsilylethynylphenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane (914673-94-2) → 3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane (914673-95-3)

Guidance literature:

With potassium fluoride; In methanol; dichloromethane; at 20 ℃;

DOI:10.1002/ejoc.200600336

Reference yield:

3,3'-bis(trimethylsilylethynyl)tolane (914673-79-3) → 3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane (914673-95-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 98 percent / potassium carbonate; methanol / CH₂Cl₂ / 1 h / 20 °C

2.1: 88 percent / Pd(PPh₃)4; CuI; triethylamine / tetrahydrofuran / 4 h / 20 °C

3.1: 95 percent / aq. HCl; tin / tetrahydrofuran / 1 h / 20 °C

4.1: BF₃*Et₂O; tert-BuONO / tetrahydrofuran / 0.5 h / -20 - -5 °C

4.2: 38 percent / KI; I₂ / acetonitrile; H₂O; CH₂Cl₂ / 16 h / 20 °C

5.1: (iPr)2NEt; PPh₃; CuI / Pd(dba)2*CHCl₃ / tetrahydrofuran

With hydrogenchloride; methanol; tin; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; boron trifluoride diethyl etherate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; Pd(dibenzylideneacetone)2 chloroform adduct; In tetrahydrofuran; dichloromethane; 2.1: Sonogashira coupling;

DOI:10.1002/ejoc.200600336

Reference yield:

1,2-bis(3-ethynylphenyl)ethyne (914673-80-6) → 3-{[5-tert-butylsulfanyl-3-(4'-ethynyl-2',3'-dinitrophenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane (914673-95-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 88 percent / Pd(PPh₃)4; CuI; triethylamine / tetrahydrofuran / 4 h / 20 °C

2.1: 95 percent / aq. HCl; tin / tetrahydrofuran / 1 h / 20 °C

3.1: BF₃*Et₂O; tert-BuONO / tetrahydrofuran / 0.5 h / -20 - -5 °C

3.2: 38 percent / KI; I₂ / acetonitrile; H₂O; CH₂Cl₂ / 16 h / 20 °C

4.1: (iPr)2NEt; PPh₃; CuI / Pd(dba)2*CHCl₃ / tetrahydrofuran

With hydrogenchloride; tin; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; boron trifluoride diethyl etherate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; Pd(dibenzylideneacetone)2 chloroform adduct; In tetrahydrofuran; 1.1: Sonogashira coupling;

DOI:10.1002/ejoc.200600336

upstream raw materials:

1,4-diethynyl-2,3-dinitrobenzene

3,3'-bis[(5-tert-butylsulfanyl-2-iodophenyl)ethynyl]tolane

3-{[5-tert-butylsulfanyl-3-(2',3'-dinitro-4'-trimethylsilylethynylphenyl)ethynyl]phenylethynyl}-3'-(5-tert-butylsulfanyl-2-iodophenylethynyl)tolane

4-fluoro-2-(methoxymethoxy)-1-nitrobenzene