N¹-benzyl-N²-[3,5-bis(trifluoromethyl)benzyl]-N²-hydroxypropane-1,2-diamine

Base Information

• Chemical Name: N¹-benzyl-N²-[3,5-bis(trifluoromethyl)benzyl]-N²-hydroxypropane-1,2-diamine
• CAS No.: 1401332-28-2
• Molecular Formula: C₁₉H₂₀F₆N₂O
• Molecular Weight: 406.371

Synonyms:N¹-benzyl-N²-[3,5-bis(trifluoromethyl)benzyl]-N²-hydroxypropane-1,2-diamine

Chemical Property of N¹-benzyl-N²-[3,5-bis(trifluoromethyl)benzyl]-N²-hydroxypropane-1,2-diamine

Chemical Property:

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Technology Process of N¹-benzyl-N²-[3,5-bis(trifluoromethyl)benzyl]-N²-hydroxypropane-1,2-diamine

There total 1 articles about N¹-benzyl-N²-[3,5-bis(trifluoromethyl)benzyl]-N²-hydroxypropane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Allylbenzylamine (4383-22-6) + 1-[3,5-bis(trifluoromethyl)phenyl]-N-hydroxymethanamine (788138-65-8) → N1-benzyl-N2-[3,5-bis(trifluoromethyl)benzyl]-N2-hydroxypropane-1,2-diamine (1401332-28-2)

Guidance literature:

In neat (no solvent); at 80 ℃; for 40h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol3023177 DOI:10.1021/ol3023177

Reference yield:

N1-benzyl-N2-[3,5-bis(trifluoromethyl)benzyl]-N2-hydroxypropane-1,2-diamine (1401332-28-2) + 1,1'-carbonyldiimidazole (530-62-1) → 5-benzyl-2-(3,5-bis(trifluoromethyl)benzyl)-3-methyl-1,2,5-oxadiazinan-6-one

Guidance literature:

In dichloromethane; Inert atmosphere;

DOI:10.1002/chem.201203462

Reference yield:

N1-benzyl-N2-[3,5-bis(trifluoromethyl)benzyl]-N2-hydroxypropane-1,2-diamine (1401332-28-2) + 1,1'-carbonyldiimidazole (530-62-1) → C20H18F6N2O2 (1453196-69-4) + (S)-5-benzyl-2-(3,5-bis(trifluoromethyl)benzyl)-3-methyl-1,2,5-oxadiazinan-6-one (1453196-68-3)

Guidance literature:

In dichloromethane; Inert atmosphere;

DOI:10.1002/chem.201203462

upstream raw materials:

Allylbenzylamine

1-[3,5-bis(trifluoromethyl)phenyl]-N-hydroxymethanamine

Downstream raw materials:

C₂₀H₁₈F₆N₂O₂

(S)-5-benzyl-2-(3,5-bis(trifluoromethyl)benzyl)-3-methyl-1,2,5-oxadiazinan-6-one

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